CALL FOR PAPERS Renal Hypoxia Modeling oxygen consumption in the proximal tubule: effects of NHE and SGLT2 inhibition
نویسندگان
چکیده
Anita T. Layton, Volker Vallon, and Aurélie Edwards Department of Mathematics, Duke University, Durham, North Carolina; Departments of Medicine and Pharmacology, University of California San Diego, La Jolla, California, and San Diego Veterans Affairs Healthcare System, San Diego, California; and Sorbonne Universités, Université Pierre et Marie Curie (UMPC) 06, Université Paris Descartes, Sorbonne Paris Cité, INSERM UMRS 1138, CNRS ERL 8228, Centre de Recherche des Cordeliers, Paris, France
منابع مشابه
Modeling oxygen consumption in the proximal tubule: effects of NHE and SGLT2 inhibition.
The objective of this study was to investigate how physiological, pharmacological, and pathological conditions that alter sodium reabsorption (TNa) in the proximal tubule affect oxygen consumption (QO2 ) and Na(+) transport efficiency (TNa/QO2 ). To do so, we expanded a mathematical model of solute transport in the proximal tubule of the rat kidney. The model represents compliant S1, S2, and S3...
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تاریخ انتشار 2015